Doxorubicin‐Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy
University of Coimbra · Institute of Marine Research
Abstract
Doxorubicin (DOX) is an anticancer anthracycline that presents a dose-dependent and cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have been advanced to explain DOX cardiac side effects, which culminate in the development of life-threatening cardiomyopathy. One of the most studied mechanisms involves the activation of DOX molecule into a more reactive semiquinone by mitochondrial Complex I, resulting in increased oxidative stress. The present review describes and critically discusses what is known about some of the potential mechanisms of DOX-induced cardiotoxicity including mitochondrial oxidative damage and loss of cardiomyocytes. We also discuss alterations of…
Citation impact
- FWCI
- 20.15
- Percentile
- 100%
- References
- 224
Authors
6Topics & keywords
- Cardiotoxicity
- Doxorubicin
- Oxidative stress
- Cardiomyopathy
- Anthracycline
- Pharmacology
- Bioenergetics
- Toxicity