Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies
Beth Israel Deaconess Medical Center · Harvard University · +6 more institutions
Abstract
The restricted neutralization breadth of vaccine-elicited antibodies is a major limitation of current human immunodeficiency virus-1 (HIV-1) candidate vaccines. In order to permit the efficient identification of vaccines with enhanced capacity for eliciting cross-reactive neutralizing antibodies (NAbs) and to assess the overall breadth and potency of vaccine-elicited NAb reactivity, we assembled a panel of 109 molecularly cloned HIV-1 Env pseudoviruses representing a broad range of genetic and geographic diversity. Viral isolates from all major circulating genetic subtypes were included, as were viruses derived shortly after transmission and during the early and chronic stages of infection. We assembled a…
Citation impact
- FWCI
- 11.58
- Percentile
- 100%
- References
- 48
Authors
19- MSMichael S. SeamanCorresponding
Beth Israel Deaconess Medical Center, Harvard University
- HJHolly Janes
Fred Hutch Cancer Center
- NHNatalie Hawkins
Fred Hutch Cancer Center
- LELauren E. Grandpre
Beth Israel Deaconess Medical Center, Harvard University
- CDColleen Devoy
Beth Israel Deaconess Medical Center, Harvard University
Topics & keywords
- Neutralization
- Virology
- Biology
- Antibody
- Virus
- Lentivirus
- Human immunodeficiency virus (HIV)
- Neutralizing antibody
- Good health and well-being