Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers
The University of Texas MD Anderson Cancer Center · Harvard University · +2 more institutions
Abstract
Abstract Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma (HNSCC). Identification of mutations that predict therapeutic response would be a major advance. We determined the mutationally altered, targetable mitogenic pathways in a large HNSCC cohort. Analysis of whole-exome sequencing data from 151 tumors revealed the phosphoinositide 3-kinase (PI3K) pathway to be the most frequently mutated oncogenic pathway (30.5%). PI3K pathway–mutated HNSCC tumors harbored a significantly higher rate of mutations in known cancer genes. In a subset of human papillomavirus-positive tumors, PIK3CA or PIK3R1 was the only mutated cancer gene. Strikingly, all tumors with concurrent mutation…
Citation impact
- FWCI
- 30.06
- Percentile
- 100%
- References
- 30
Authors
29- VWVivian Wai Yan Lui
The University of Texas MD Anderson Cancer Center, Harvard University, University of Pittsburgh, Dana-Farber Cancer Institute
- MLMatthew L. Hedberg
The University of Texas MD Anderson Cancer Center, Harvard University, University of Pittsburgh, Dana-Farber Cancer Institute
- HLHua Li
The University of Texas MD Anderson Cancer Center, Harvard University, University of Pittsburgh, Dana-Farber Cancer Institute
- BSBhavana S. Vangara
The University of Texas MD Anderson Cancer Center, Harvard University, University of Pittsburgh, Dana-Farber Cancer Institute
- KPKelsey Pendleton
The University of Texas MD Anderson Cancer Center, Harvard University, University of Pittsburgh, Dana-Farber Cancer Institute
Topics & keywords
- PI3K/AKT/mTOR pathway
- Head and neck squamous-cell carcinoma
- Cancer research
- Biology
- Cancer
- Mutation
- P110α
- Exome sequencing
- Good health and well-being