Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
Brigham and Women's Hospital · Harvard University
Abstract
The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving biosynthesis of potent antiinflammatory and proresolving mediators from the essential fatty acid docosahexaenoic acid (DHA) by macrophages (MPhis). During the resolution of mouse peritonitis, exudates accumulated both 17-hydroxydocosahexaenoic acid, a known marker of 17S-D series resolvin (Rv) and protectin biosynthesis, and 14S-hydroxydocosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid from endogenous DHA. Addition of either DHA or 14S-hydroperoxydocosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid to…
Citation impact
- FWCI
- 24.04
- Percentile
- 100%
- References
- 36
Authors
8- CNCharles N. SerhanCorresponding
Brigham and Women's Hospital, Harvard University
- RYRong Yang
Brigham and Women's Hospital, Harvard University
- KMKimberly Martinod
Brigham and Women's Hospital, Harvard University
- KKKie Kasuga
Brigham and Women's Hospital, Harvard University
- PSPadmini S. Pillai
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Docosahexaenoic acid
- Lipid signaling
- Endogeny
- Inflammation
- Biochemistry
- Oxylipin
- Chemistry
- Fatty acid
- Good health and well-being