reviewCirculationJun 28, 2005BRONZE OA

Pathophysiology of Coronary Artery Disease

PLPeter LibbyPTPierre Théroux

Montreal Heart Institute

PubMed
Indexed incrossrefpubmed

Abstract

During the past decade, our understanding of the pathophysiology of coronary artery disease (CAD) has undergone a remarkable evolution. We review here how these advances have altered our concepts of and clinical approaches to both the chronic and acute phases of CAD. Previously considered a cholesterol storage disease, we currently view atherosclerosis as an inflammatory disorder. The appreciation of arterial remodeling (compensatory enlargement) has expanded attention beyond stenoses evident by angiography to encompass the biology of nonstenotic plaques. Revascularization effectively relieves ischemia, but we now recognize the need to attend to nonobstructive lesions as well. Aggressive management of…

Citation impact

1,978
total citations
FWCI
76.31
Percentile
100%
References
59
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Medicine
  • Coronary artery disease
  • Revascularization
  • Cardiology
  • Pathophysiology
  • Disease
  • Internal medicine
  • Culprit
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding