Tissue-specific expression and regulation of sexually dimorphic genes in mice
University of California, Los Angeles · Merck & Co., Inc., Rahway, NJ, USA (United States) · +1 more institution
Abstract
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ. The analysis of a large number of individuals provided the power to detect relatively small differences in expression between sexes, and the use of an intercross allowed analysis of the genetic control of sexually dimorphic gene expression. Microarray analysis of 23,574 transcripts revealed that the extent of sexual dimorphism in gene expression was much greater than previously recognized. Thus, thousands of genes showed sexual dimorphism in liver, adipose, and muscle, and hundreds of genes were sexually dimorphic…
Citation impact
- FWCI
- —
- Percentile
- —
- References
- 60
Authors
8- XYXia YangCorresponding
University of California, Los Angeles
- EEEric E. Schadt
Merck & Co., Inc., Rahway, NJ, USA (United States), Rosetta Stone (United States)
- SWSusanna Wang
University of California, Los Angeles
- HWHui Wang
University of California, Los Angeles
- APArthur P. Arnold
University of California, Los Angeles
Topics & keywords
- Biology
- Sexual dimorphism
- Gene
- Genetics
- Expression quantitative trait loci
- Gene expression
- Quantitative trait locus
- Regulation of gene expression