Chemical biology of anticancer gold( iii ) and gold( i ) complexes
Institute of Molecular Functional Materials · State Key Laboratory of Synthetic Chemistry · +2 more institutions
Abstract
Gold complexes have recently gained increasing attention in the design of new metal-based anticancer therapeutics. Gold(III) complexes are generally reactive/unstable under physiological conditions via intracellular redox reactions, and the intracellular Au(III) to Au(I) reduction reaction has recently been "traced" by the introduction of appropriate fluorescent ligands. Similar to most Au(I) complexes, Au(III) complexes can inhibit the activities of thiol-containing enzymes, including thioredoxin reductase, via ligand exchange reactions to form Au-S(Se) bonds. Nonetheless, there are examples of physiologically stable Au(III) and Au(I) complexes, such as [Au(TPP)]Cl (H2TPP = 5,10,15,20-tetraphenylporphyrin)…
Citation impact
- FWCI
- 24.82
- Percentile
- 100%
- References
- 108
Authors
5- TZTaotao Zou
Institute of Molecular Functional Materials, State Key Laboratory of Synthetic Chemistry, Czech Academy of Sciences, Biology Centre, University of Hong Kong
- CTChing Tung Lum
Institute of Molecular Functional Materials, State Key Laboratory of Synthetic Chemistry, Czech Academy of Sciences, Biology Centre, University of Hong Kong
- CLChun‐Nam Lok
Institute of Molecular Functional Materials, State Key Laboratory of Synthetic Chemistry, Czech Academy of Sciences, Biology Centre, University of Hong Kong
- JZJing‐Jing Zhang
Institute of Molecular Functional Materials, State Key Laboratory of Synthetic Chemistry, Czech Academy of Sciences, Biology Centre, University of Hong Kong
- CCChi‐Ming CheCorresponding
Institute of Molecular Functional Materials, State Key Laboratory of Synthetic Chemistry, Czech Academy of Sciences, Biology Centre, University of Hong Kong
Topics & keywords
- Chemistry
- Combinatorial chemistry