reviewThe FASEB JournalApr 29, 2004Closed access

TGF‐β signaling and the fibrotic response

ALAndrew LeaskDADavid Abraham

The Royal Free Hospital · Roland Hill (United Kingdom) · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

The cause of fibrotic diseases, pathologies characterized by excessive production, deposition, and contraction of extracellular matrix, is unknown. To understand the molecular basis of fibrotic disease, it is essential to appreciate how matrix deposition is normally controlled and how this process is dysregulated in fibrogenesis. This review discusses the current state of knowledge concerning interactions among the profibrotic proteins transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF, CCN2), and ED-A fibronectin (ED-A FN) and the antifibrotic proteins tumor necrosis factor-alpha (TNF-alpha) and gamma-interferon (IFN-gamma).

Citation impact

2,272
total citations
FWCI
30.25
Percentile
100%
References
154
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • CTGF
  • Extracellular matrix
  • Fibronectin
  • Transforming growth factor beta
  • Transforming growth factor
  • Connective tissue
  • Fibrosis
  • Transforming growth factor, beta 3
UN Sustainable Development Goals
  • Good health and well-being
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Funding