reviewAngewandte Chemie International EditionJul 27, 2009Closed access

The Challenge of Atropisomerism in Drug Discovery

JCJonathan ClaydenWJWesley J. MoranPEPaul EdwardsSRSteven R. LaPlante

University of Manchester · Boehringer Ingelheim (Germany) · +1 more institution

PubMed
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Abstract

A twist in the tale: Recent reports have highlighted solutions to the problems encountered when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme). This Minireview brings together the various strategies that have been adopted and proposes a general approach to handling an aspect of stereochemistry which has received little attention from drug regulatory agencies.

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760
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FWCI
9.71
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100%
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40
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Authors

4

Topics & keywords

Topics
Keywords
  • Atropisomer
  • Drug discovery
  • Drug
  • Conformational isomerism
  • Chemistry
  • Computational biology
  • Nanotechnology
  • Stereochemistry
UN Sustainable Development Goals
  • Good health and well-being
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