The human circadian metabolome

The circadian clock orchestrates many aspects of human physiology, and disruption of this clock has been implicated in various pathologies, ranging from cancer to metabolic syndrome and diabetes. Although there is evidence that metabolism and the circadian clockwork are intimately linked on a transcriptional level, whether these effects are directly under clock control or are mediated by the rest-activity cycle and the timing of food intake is unclear. To answer this question, we conducted an unbiased screen in human subjects of the metabolome of blood plasma and saliva at different times of day. To minimize indirect effects, subjects were kept in a 40-h constant routine of enforced posture, constant dim…

• NS
  National Science Foundation
• AV
  Alexander von Humboldt-Stiftung
• VS
  Velux Stiftung
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
• HM
  Hartmann Müller-Stiftung für Medizinische Forschung