The Role of Oxidative Stress and Antioxidants in Liver Diseases
Chinese University of Hong Kong · University of Hong Kong
Abstract
A complex antioxidant system has been developed in mammals to relieve oxidative stress. However, excessive reactive species derived from oxygen and nitrogen may still lead to oxidative damage to tissue and organs. Oxidative stress has been considered as a conjoint pathological mechanism, and it contributes to initiation and progression of liver injury. A lot of risk factors, including alcohol, drugs, environmental pollutants and irradiation, may induce oxidative stress in liver, which in turn results in severe liver diseases, such as alcoholic liver disease and non-alcoholic steatohepatitis. Application of antioxidants signifies a rational curative strategy to prevent and cure liver diseases involving…
Citation impact
- FWCI
- 57.08
- Percentile
- 100%
- References
- 262
Authors
7- SLSha LiCorresponding
Chinese University of Hong Kong, University of Hong Kong
- HTHor‐Yue Tan
Chinese University of Hong Kong, University of Hong Kong
- NWNing Wang
Chinese University of Hong Kong, University of Hong Kong
- ZZZhang-Jin Zhang
Chinese University of Hong Kong, University of Hong Kong
- LLLixing Lao
Chinese University of Hong Kong, University of Hong Kong
Topics & keywords
- Oxidative stress
- Antioxidant
- Reactive oxygen species
- Medicine
- Oxidative phosphorylation
- Pharmacology
- Reactive nitrogen species
- Liver injury