25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Brigham and Women's Hospital · Harvard University · +4 more institutions
Abstract
Hydrogels are hydrophilic polymer-based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three-dimensional (3D) matrices for tissue engineering, drug-delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biological properties can be used to modulate cellular functionality and tissue morphogenesis. Here, the development of advanced hydrogels with tunable physiochemical properties is highlighted, with particular…
Citation impact
- FWCI
- 44.09
- Percentile
- 100%
- References
- 464
Authors
10- NANasim Annabi
Brigham and Women's Hospital, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- ATAli Tamayol
Brigham and Women's Hospital, Harvard University, Harvard University Press, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- JAJorge Alfredo Uquillas
Brigham and Women's Hospital, Harvard University, Harvard University Press, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- MAMohsen Akbari
Brigham and Women's Hospital, Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- LELuiz E. Bertassoni
Brigham and Women's Hospital, Harvard University, Harvard University Press, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
Topics & keywords
- Self-healing hydrogels
- Regenerative medicine
- Materials science
- Nanotechnology
- Tissue engineering
- Drug delivery
- Rational design
- Elastomer