The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines
Manchester Academic Health Science Centre · University of Manchester · +1 more institution
Abstract
Diurnal variation in inflammatory and immune function is evident in the physiology and pathology of humans and animals, but molecular mechanisms and mediating cell types that provide this gating remain unknown. By screening cytokine responses in mice to endotoxin challenge at different times of day, we reveal that the magnitude of response exhibited pronounced temporal dependence, yet only within a subset of proinflammatory cytokines. Disruption of the circadian clockwork in macrophages (primary effector cells of the innate immune system) by conditional targeting of a key clock gene (bmal1) removed all temporal gating of endotoxin-induced cytokine response in cultured cells and in vivo. Loss of circadian…
Citation impact
- FWCI
- 11.28
- Percentile
- 100%
- References
- 34
Authors
11- JGJulie GibbsCorresponding
Manchester Academic Health Science Centre, University of Manchester
- JBJohn Blaikley
Manchester Academic Health Science Centre, University of Manchester
- SBStephen Beesley
Manchester Academic Health Science Centre, University of Manchester
- LMLaura Matthews
Manchester Academic Health Science Centre, University of Manchester
- KDKaren D. Simpson
GlaxoSmithKline (United Kingdom)
Topics & keywords
- Proinflammatory cytokine
- Circadian rhythm
- Biology
- Circadian clock
- Cell biology
- Immune system
- Innate immune system
- Cytokine
- Good health and well-being