α-Synuclein Locus Triplication Causes Parkinson's Disease

Singleton, A. B.; Singleton, Andrew; Farrer, Matthew J.; Johnson, Janel; Singleton, Andrew; Singleton, A.; Hague, Stephen; Kachergus, Jennifer M.; Hulihan, Mary; Peuralinna, Terhi; Dutra, A.; Nussbaum, Robert; Lincoln, S.; Crawley, Anthony; Hanson, M; Maraganore, Demetrius M.; Adler, Charles H.; Cookson, Mark; Muenter, Manfred D.; Baptista, Maria Fortuna; Miller, David W.; Blancato, Jan; Hardy, John; Gwinn, Katrina

doi:10.1126/science.1090278

articleScienceOct 30, 2003Closed access

α-Synuclein Locus Triplication Causes Parkinson's Disease

ABA. B. SingletonASAndrew Singleton MJMatthew J. Farrer JJJanel Johnson ASAndrew Singleton

National Institutes of Health · Mayo Clinic · +6 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Impaired Autophagic-Lysosomal Fusion in Parkinson's Patient Midbrain Neurons Occurs through Loss of ykt6 and Is Rescued by Farnesyltransferase Inhibition,

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Authors

24

AB
A. B. Singleton
National Institutes of Health, Mayo Clinic, Jacksonville College, WinnMed, National Human Genome Research Institute, National Institute of Neurological Disorders and Stroke, National Institute on Aging, Mayo Clinic in Florida
AS
Andrew SingletonCorresponding
National Institutes of Health, Mayo Clinic, Jacksonville College, WinnMed, National Human Genome Research Institute, National Institute of Neurological Disorders and Stroke, National Institute on Aging, Mayo Clinic in Florida
MJ
Matthew J. FarrerCorresponding
National Institutes of Health, Mayo Clinic, Jacksonville College, WinnMed, National Human Genome Research Institute, National Institute of Neurological Disorders and Stroke, National Institute on Aging, Mayo Clinic in Florida
JJ
Janel Johnson
National Institutes of Health, Mayo Clinic, Jacksonville College, WinnMed, National Human Genome Research Institute, National Institute of Neurological Disorders and Stroke, National Institute on Aging, Mayo Clinic in Florida
AS
Andrew SingletonCorresponding
National Institutes of Health, Mayo Clinic, Jacksonville College, WinnMed, National Human Genome Research Institute, National Institute of Neurological Disorders and Stroke, National Institute on Aging, Mayo Clinic in Florida

Topics & keywords

Topics

Keywords

Parkinson's disease
Locus (genetics)
Disease
Neuroscience
Genetics
Biology
Medicine
Internal medicine

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