Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells
Harvard University · Harvard–MIT Division of Health Sciences and Technology · +1 more institution
Abstract
To better direct repair following spinal cord injury (SCI), we designed an implant modeled after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with neural stem cells. Implantation of the scaffold-neural stem cells unit into an adult rat hemisection model of SCI promoted long-term improvement in function (persistent for 1 year in some animals) relative to a lesion-control group. At 70 days postinjury, animals implanted with scaffold-plus-cells exhibited coordinated, weight-bearing hindlimb stepping. Histology and immunocytochemical analysis suggested that this recovery might be attributable partly to a reduction in tissue loss from secondary injury processes as well as in…
Citation impact
- FWCI
- 23.07
- Percentile
- 100%
- References
- 35
Authors
8- YDYang D. TengCorresponding
Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- ELErin Lavik
Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- XQXianlu Qu
Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- KIKook I. Park
Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
- JOJitka Ourednik
Harvard University, Harvard–MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology
Topics & keywords
- Spinal cord injury
- Spinal cord
- Neural stem cell
- Stem cell
- Regeneration (biology)
- Medicine
- Lesion
- Corticospinal tract
- Good health and well-being