Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

The enzymes catalyzing lysine and arginine methylation of histones are essential for maintaining transcriptional programs and determining cell fate and identity. Until recently, histone methylation was regarded irreversible. However, within the last few years, several families of histone demethylases erasing methyl marks associated with gene repression or activation have been identified, underscoring the plasticity and dynamic nature of histone methylation. Recent discoveries have revealed that histone demethylases take part in large multiprotein complexes synergizing with histone deacetylases, histone methyltransferases, and nuclear receptors to control developmental and transcriptional programs. Here we…

• KB
  Kræftens Bekæmpelse
• SO
  Sundhed og Sygdom, Det Frie Forskningsråd
• EC
  European Commission
• NR
  National Research Foundation
• DG
  Danmarks Grundforskningsfond
• NN
  Novo Nordisk
• NN
  Novo Nordisk Fonden
• MR
  Medical Research Council