articleScienceJul 20, 2007GREEN OA

A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

JFJacques FellayKVKevin V. ShiannaDGDongliang GeSCSara ColomboBLBruno Ledergerber

Duke University · University Hospital of Zurich · +8 more institutions

PubMed
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Abstract

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings…

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Authors

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Topics & keywords

Topics
Keywords
  • Human immunodeficiency virus (HIV)
  • Association (psychology)
  • Host (biology)
  • Genome-wide association study
  • Genome
  • Biology
  • Genetic association
  • Computational biology
UN Sustainable Development Goals
  • Good health and well-being
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