articleLearning & MemoryNov 1, 2006DIAMOND OA

Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear

IVIvan Vidal-GonzalezBVBenjamín Vidal-GonzalezSLScott L. RauchGJGregory J. Quirk

Ponce Health Sciences University · Harvard University · +1 more institution

Indexed incrossref

Abstract

Recent studies using lesion, infusion, and unit-recording techniques suggest that the infralimbic (IL) subregion of medial prefrontal cortex (mPFC) is necessary for the inhibition of conditioned fear following extinction. Brief microstimulation of IL paired with conditioned tones, designed to mimic neuronal tone responses, reduces the expression of conditioned fear to the tone. In the present study we used microstimulation to investigate the role of additional mPFC subregions: the prelimbic (PL), dorsal anterior cingulate (ACd), and medial precentral (PrCm) cortices in the expression and extinction of conditioned fear. These are tone-responsive areas that have been implicated in both acquisition and extinction…

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Topics & keywords

Topics
Keywords
  • Microstimulation
  • Extinction (optical mineralogy)
  • Infralimbic cortex
  • Neuroscience
  • Prefrontal cortex
  • Amygdala
  • Psychology
  • Fear processing in the brain
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