The Genomic Landscape of Pediatric Ewing Sarcoma
Dana-Farber Cancer Institute · Broad Institute · +8 more institutions
Abstract
UNLABELLED: Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and ETS family transcription factors, representing a paradigm for studying cancers driven by transcription factor rearrangements. In this study, we describe the somatic landscape of pediatric Ewing sarcoma. These tumors are among the most genetically normal cancers characterized to date, with only EWS-ETS rearrangements identified in the majority of tumors. STAG2 loss, however, is present in more than 15% of Ewing sarcoma tumors; occurs by point mutation, rearrangement, and likely nongenetic mechanisms; and is associated with disease dissemination. Perhaps the most striking finding is the paucity of mutations in…
Citation impact
- FWCI
- 27.15
- Percentile
- 100%
- References
- 76
Authors
34- BDBrian D. CromptonCorresponding
Dana-Farber Cancer Institute
- CSChip Stewart
Broad Institute, Eli and Edythe Broad Foundation
- ATAmaro Taylor‐Weiner
Broad Institute, Eli and Edythe Broad Foundation
- GAGabriela Alexe
Broad Institute, Boston University, University of Massachusetts Boston, Dana-Farber Cancer Institute, Eli and Edythe Broad Foundation
- KCKyle C. Kurek
Boston Children's Hospital, Boston Children's Museum
Topics & keywords
- Sarcoma
- Pediatric cancer
- Cancer research
- Biology
- Ewing's sarcoma
- FLI1
- Point mutation
- Cancer
- Good health and well-being