Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases

Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulation. Evidence from murine and human studies has suggested that monocytosis can be an indicator of various inflammatory diseases. Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into tissue macrophages or dendritic cells. Given the rapid progress in monocyte research from broad spectrum of inflammatory diseases, there is a need to summarize our knowledge in monocyte…

• NI
  National Institutes of Health

  Awards: HL110764, HL82774, HL116917, HL108910, HL9445, HL77288, HL117654, HL67033