Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

Primary ovarian insufficiency (POI) and polycystic ovarian syndrome are ovarian diseases causing infertility. Although there is no effective treatment for POI, therapies for polycystic ovarian syndrome include ovarian wedge resection or laser drilling to induce follicle growth. Underlying mechanisms for these disruptive procedures are unclear. Here, we explored the role of the conserved Hippo signaling pathway that serves to maintain optimal size across organs and species. We found that fragmentation of murine ovaries promoted actin polymerization and disrupted ovarian Hippo signaling, leading to increased expression of downstream growth factors, promotion of follicle growth, and the generation of mature…

• CI
  California Institute of Regenerative Medicine
• AP
  Astellas Pharma
• NI
  National Institutes of Health

  Award: U54 HD068158
• NI
  National Institute of Child Health and Human Development

  Award: U54 HD068158