Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Howard Hughes Medical Institute · University of California, Los Angeles · +3 more institutions
Abstract
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-regulated expression of the vitamin D receptor and the vitamin D-1-hydroxylase genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to tuberculosis, had low 25-hydroxyvitamin D and were inefficient in supporting cathelicidin messenger RNA…
Citation impact
- FWCI
- 105.56
- Percentile
- 100%
- References
- 24
Authors
22- PTPhilip T. LiuCorresponding
Howard Hughes Medical Institute, University of California, Los Angeles, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, VA San Diego Healthcare System
- SSSteffen StengerCorresponding
Howard Hughes Medical Institute, University of California, Los Angeles, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, VA San Diego Healthcare System
- HLHuiying Li
Howard Hughes Medical Institute, University of California, Los Angeles, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, VA San Diego Healthcare System
- LWLinda Wenzel
Howard Hughes Medical Institute, University of California, Los Angeles, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, VA San Diego Healthcare System
- BHBelinda H. Tan
Howard Hughes Medical Institute, University of California, Los Angeles, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, VA San Diego Healthcare System
Topics & keywords
- Cathelicidin
- Innate immune system
- Antimicrobial peptides
- Mycobacterium tuberculosis
- Microbiology
- Immune system
- TLR2
- Biology
- Good health and well-being