Increased oxidative stress in obesity and its impact on metabolic syndrome

Obesity is a principal causative factor in the development of metabolic syndrome. Here we report that increased oxidative stress in accumulated fat is an important pathogenic mechanism of obesity-associated metabolic syndrome. Fat accumulation correlated with systemic oxidative stress in humans and mice. Production of ROS increased selectively in adipose tissue of obese mice, accompanied by augmented expression of NADPH oxidase and decreased expression of antioxidative enzymes. In cultured adipocytes, elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation, and oxidative stress caused dysregulated production of adipocytokines (fat-derived hormones), including adiponectin,…

• NF
  Naito Foundation
• SM
  Suzuken Memorial Foundation
• CS
  Cell Science Research Foundation
• NF
  Novartis Foundation
• JR
  Japan Research Foundation for Clinical Pharmacology
• TB
  Tokyo Biochemical Research Foundation
• MO
  Ministry of Education, Culture, Sports, Science and Technology
• KM
  Kato Memorial Bioscience Foundation
• MM
  Mochida Memorial Foundation for Medical and Pharmaceutical Research
• JH
  Japan Heart Foundation
• JS
  Japan Society for the Promotion of Science