The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer
NewYork–Presbyterian Hospital · Cornell University · +16 more institutions
Abstract
The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR status. However, the role of ERα remains elusive. Using a combination of chromatin immunoprecipitation (ChIP) and RNA-sequencing data, we identified an ERα-specific non-coding transcriptome signature. Among putatively ERα-regulated intergenic long non-coding RNAs (lncRNAs), we identified nuclear enriched abundant transcript 1 (NEAT1) as the most significantly overexpressed lncRNA in prostate cancer.…
Citation impact
- FWCI
- 19.67
- Percentile
- 100%
- References
- 59
Authors
26- DCDimple ChakravartyCorresponding
NewYork–Presbyterian Hospital, Cornell University, Presbyterian Hospital
- ASAndrea Sboner
NewYork–Presbyterian Hospital, Cornell University, Presbyterian Hospital
- SSSujit S. Nair
George Washington University
- ΕΓΕυγενία Γιαννοπούλου
City University of New York, New York City College of Technology
- RLRuohan Li
The University of Western Australia
Topics & keywords
- Prostate cancer
- Androgen receptor
- Cancer research
- Chromatin immunoprecipitation
- Biology
- Long non-coding RNA
- Epigenetics
- Transcriptome
- Good health and well-being