Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?
Institució Catalana de Recerca i Estudis Avançats · Universitat Pompeu Fabra · +4 more institutions
Abstract
Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. Muscle is also an important target of the cytokine. IL-6 signaling has been associated with stimulation of hypertrophic muscle growth and myogenesis through regulation of the proliferative capacity of muscle stem cells. Additional beneficial effects of IL-6 include regulation of energy metabolism, which is related to the capacity of actively contracting muscle to synthesize and release IL-6. Paradoxically, deleterious actions for IL-6 have also been proposed, such as promotion of atrophy…
Citation impact
- FWCI
- 32.62
- Percentile
- 100%
- References
- 158
Authors
4- PMPura Muñoz‐CánovesCorresponding
Institució Catalana de Recerca i Estudis Avançats, Universitat Pompeu Fabra, Biomedical Research Networking Center on Neurodegenerative Diseases
- CSCamilla Schéele
University of Copenhagen, Copenhagen University Hospital, Rigshospitalet
- BKBente Klarlund Pedersen
University of Copenhagen, Copenhagen University Hospital, Rigshospitalet
- ALAntonio L. SerranoCorresponding
Institució Catalana de Recerca i Estudis Avançats, Universitat Pompeu Fabra, Biomedical Research Networking Center on Neurodegenerative Diseases
Topics & keywords
- Myokine
- SWORD
- Skeletal muscle
- Cell biology
- Chemistry
- Biology
- Endocrinology
- Computer science
- Affordable and clean energy