Autophagy and apoptosis dysfunction in neurodegenerative disorders
Children's Hospital Research Institute of Manitoba · University of Manitoba · +12 more institutions
Abstract
Autophagy and apoptosis are basic physiologic processes contributing to the maintenance of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic proteins and damaged organelles. It involves a sequential set of events including double membrane formation, elongation, vesicle maturation and finally delivery of the targeted materials to the lysosome. Apoptotic cell death is best described through its morphology. It is characterized by cell rounding, membrane blebbing, cytoskeletal collapse, cytoplasmic condensation, and fragmentation, nuclear pyknosis, chromatin condensation/fragmentation, and formation of membrane-enveloped apoptotic bodies, that are rapidly phagocytosed by…
Citation impact
- FWCI
- 43.62
- Percentile
- 100%
- References
- 401
Authors
13- SGSaeid Ghavami
Children's Hospital Research Institute of Manitoba, University of Manitoba, St. Boniface Hospital
- SSShahla Shojaei
Shiraz University of Medical Sciences
- BYBehzad Yeganeh
University of Toronto, University of Manitoba, Hospital for Sick Children, SickKids Foundation, Children's Hospital Research Institute of Manitoba
- SRSudharsana Rao Ande
University of Manitoba
- JRJaganmohan R. Jangamreddy
Linköping University
Topics & keywords
- Autophagy
- Cell biology
- Biology
- Neurodegeneration
- Programmed cell death
- Neuroscience
- Autophagosome
- Lysosome
- Good health and well-being