EZH2 Expression Is Associated With High Proliferation Rate and Aggressive Tumor Subgroups in Cutaneous Melanoma and Cancers of the Endometrium, Prostate, and Breast
Haukeland University Hospital · University of Bergen · +5 more institutions
Abstract
PURPOSE: EZH2 is a member of the polycomb group of genes and important in cell cycle regulation. Increased expression of EZH2 has been associated previously with invasive growth and aggressive clinical behavior in prostate and breast cancer, but the relationship with tumor cell proliferation has not been examined in human tumors. The purpose of this study was to validate previous findings in a population-based setting, also including tumors that have not been studied previously. PATIENTS AND METHODS: In our study of nearly 700 patients, we examined EZH2 expression and its association with tumor cell proliferation and other tumor markers, clinical features, and prognosis in cutaneous melanoma and cancers of the…
Citation impact
- FWCI
- 7.20
- Percentile
- 100%
- References
- 23
Authors
9- IBIngeborg Bachmann
Haukeland University Hospital, University of Bergen, University of Amsterdam
- OJOle J. Halvorsen
Netherlands Institute for Neuroscience, Harvard University, Haukeland University Hospital, Family Research Institute, Children's Hospital, University of Bergen, University of Amsterdam
- KCKarin Collett
Netherlands Institute for Neuroscience, Harvard University, Haukeland University Hospital, Family Research Institute, Children's Hospital, University of Bergen, University of Amsterdam
- IMIngunn M. Stefansson
Netherlands Institute for Neuroscience, Harvard University, Haukeland University Hospital, Family Research Institute, Children's Hospital, University of Bergen, University of Amsterdam
- OSOddbjørn Straume
Netherlands Institute for Neuroscience, Harvard University, Haukeland University Hospital, Family Research Institute, Children's Hospital, University of Bergen, University of Amsterdam
Topics & keywords
- Medicine
- Prostate
- Oncology
- Melanoma
- Endometrium
- Internal medicine
- Cancer research
- Cancer
- Good health and well-being