MicroRNA-based regulation of epithelial–hybrid–mesenchymal fate determination
Center for Theoretical Biological Physics · Astronomy and Space · +2 more institutions
Abstract
Forward and backward transitions between epithelial and mesenchymal phenotypes play crucial roles in embryonic development and tissue repair. Aberrantly regulated transitions are also a hallmark of cancer metastasis. The genetic network that regulates these transitions appears to allow for the existence of a hybrid phenotype (epithelial/mesenchymal). Hybrid cells are endowed with mixed epithelial and mesenchymal characteristics, enabling specialized capabilities such as collective cell migration. Cell-fate determination between the three phenotypes is in fact regulated by a circuit composed of two highly interconnected chimeric modules--the miR-34/SNAIL and the miR-200/ZEB mutual-inhibition feedback circuits.…
Citation impact
- FWCI
- 13.77
- Percentile
- 100%
- References
- 70
Authors
5- MLMingyang LuCorresponding
Center for Theoretical Biological Physics
- MKMohit Kumar Jolly
Center for Theoretical Biological Physics
- HLHerbert Levine
Center for Theoretical Biological Physics, Astronomy and Space
- JNJosé N. Onuchic
Center for Theoretical Biological Physics, Astronomy and Space, Rice University
- EBEshel Ben‐Jacob
Tel Aviv University, Center for Theoretical Biological Physics, Rice University
Topics & keywords
- Mesenchymal stem cell
- microRNA
- Cell biology
- Cell fate determination
- Embryonic stem cell
- Biology
- Phenotype
- Epithelial–mesenchymal transition