MicroRNA Expression Profiling in Human Ovarian Cancer: miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN
University of South Florida · Moffitt Cancer Center · +1 more institution
Abstract
MicroRNAs (miRNA) represent a novel class of genes that function as negative regulators of gene expression. Recently, miRNAs have been implicated in several cancers. However, aberrant miRNA expression and its clinicopathologic significance in human ovarian cancer have not been well documented. Here, we show that several miRNAs are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, miR-199a*, miR-200a, miR-100, miR-125b, and let-7 cluster. Further, we show the frequent deregulation of miR-214, miR-199a*, miR-200a, and miR-100 in ovarian cancers. Significantly, miR-214 induces cell survival and cisplatin resistance through targeting the 3'-untranslated region (UTR) of…
Citation impact
- FWCI
- 35.44
- Percentile
- 100%
- References
- 33
Authors
11- HYHua YangCorresponding
University of South Florida, Moffitt Cancer Center, Florida College
- WKWilliam Kong
University of South Florida, Moffitt Cancer Center, Florida College
- LHLili He
University of South Florida, Moffitt Cancer Center, Florida College
- JZJianjun Zhao
University of South Florida, Moffitt Cancer Center, Florida College
- JDJoshua D. O’Donnell
University of South Florida, Moffitt Cancer Center, Florida College
Topics & keywords
- PTEN
- microRNA
- Ovarian cancer
- Cancer research
- Protein kinase B
- Biology
- Cisplatin
- PI3K/AKT/mTOR pathway
- Good health and well-being