Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
Johns Hopkins University · University of Tsukuba · +1 more institution
Abstract
Induction of a family of phase 2 genes encoding for proteins that protect against the damage of electrophiles and reactive oxygen intermediates is potentially a major strategy for reducing the risk of cancer and chronic degenerative diseases. Many phase 2 genes are regulated by upstream antioxidant response elements (ARE) that are targets of the leucine zipper transcription factor Nrf2. Under basal conditions, Nrf2 resides mainly in the cytoplasm bound to its cysteine-rich, Kelch domain-containing partner Keap1, which is itself anchored to the actin cytoskeleton and represses Nrf2 activity. Inducers disrupt the Keap1-Nrf2 complex by modifying two (C273 and C288) of the 25 cysteine residues of Keap1. The…
Citation impact
- FWCI
- 22.42
- Percentile
- 100%
- References
- 50
Authors
8- NWNobunao Wakabayashi
Johns Hopkins University, University of Tsukuba, Japan Science and Technology Agency
- ATAlbena T. Dinkova‐Kostova
Johns Hopkins University, University of Tsukuba, Japan Science and Technology Agency
- WDW. David Holtzclaw
Johns Hopkins University, University of Tsukuba, Japan Science and Technology Agency
- MKMoon-Il Kang
Johns Hopkins University, University of Tsukuba, Japan Science and Technology Agency
- AKAkira Kobayashi
Johns Hopkins University, University of Tsukuba, Japan Science and Technology Agency
Topics & keywords
- Inducer
- KEAP1
- Electrophile
- Phase (matter)
- Chemistry
- Biochemistry
- Organic chemistry
- Good health and well-being