Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
Massachusetts Institute of Technology · Broad Institute · +1 more institution
Abstract
Analysis of transcriptional and epigenomic changes in the hippocampus of a mouse model of Alzheimer’s disease shows that immune function genes and regulatory regions are upregulated, whereas genes and regulatory regions involved in synaptic plasticity, learning and memory are downregulated; genetic variants associated with Alzheimer’s disease are only enriched in orthologues of upregulated immune regions, suggesting that dysregulation of immune processes may underlie Alzheimer’s disease predisposition. Recent genome-wide association studies have shown substantial genetic variation in non-coding regions associated with Alzheimer's disease, suggesting the involvement of aberrant gene regulation. However, the…
Citation impact
- FWCI
- 35.54
- Percentile
- 100%
- References
- 63
Authors
7- EGElizabeta GjoneskaCorresponding
Massachusetts Institute of Technology
- APAndreas Pfenning
Broad Institute, Massachusetts Institute of Technology, Harvard University
- HMHansruedi Mathys
Massachusetts Institute of Technology
- GQGerald Quon
Massachusetts Institute of Technology, Harvard University, Broad Institute
- AKAnshul Kundaje
Harvard University, Broad Institute, Massachusetts Institute of Technology
Topics & keywords
- Neurodegeneration
- Biology
- Enhancer
- Chromatin
- Epigenomics
- Genetics
- Alzheimer's disease
- Gene
Funding
- NSNational Science Foundation
- SNSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungAward: P2BSP3_151885
- NINational Institutes of HealthAward: R01HG004037
- NINational Institute on Aging
- NHNational Human Genome Research Institute
- NINational Institute of Neurological Disorders and Stroke