In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

Pillay, Janesh; Braber, Ineke den; Vrisekoop, Nienke; Kwast, Lydia M.; Boer, Rob J. de; Borghans, José A. M.; Tesselaar, Kiki; Koenderman, Leo

doi:10.1182/blood-2010-01-259028

articleBloodApr 22, 2010Closed access

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

JPJanesh Pillay IDIneke den Braber NVNienke Vrisekoop LMLydia M. Kwast RJRob J. de Boer

University Medical Center Utrecht · Utrecht University

PubMed

Indexed incrossrefpubmed

Abstract

Neutrophils are essential effector cells of the innate immune response and are indispensable for host defense. Apart from their antimicrobial functions, neutrophils inform and shape subsequent immunity. This immune modulatory functionality might however be considered limited because of their generally accepted short lifespan (

Citation impact

854

total citations

FWCI: 12.91
Percentile: 100%
References: 18

Citations per year

Authors

8

Topics & keywords

Topics

Keywords

In vivo
Innate immune system
Effector
Biology
Ex vivo
Immunology
Immune system
Immunity

No related works found for this paper.