Biological interpretation of genome-wide association studies using predicted gene functions

The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes. Identifying which genes and pathways explain genetic associations is challenging. Here, the authors present DEPICT, a tool for gene prioritization, pathway analysis and tissue/cell-type…

• NO
  Nederlandse Organisatie voor Wetenschappelijk Onderzoek

  Award: FP7/2007-2013
• DF
  Danmarks Frie Forskningsfond
• AB
  Alfred Benzon Foundation
• NI
  National Institutes of Health

  Award: FP7/2007-2013
• MR
  Medical Research Council

  Awards: MR/K013351/1, MR/K006584/1, MR/N01104X/1
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: 2R01DK075787
• NI
  National Institute of Child Health and Human Development
• EK
  Eunice Kennedy Shriver National Institute of Child Health and Human Development