Investigating the optimal size of anticancer nanomedicine
Division of Materials Science and Engineering · Guangdong Pharmaceutical University · +5 more institutions
Abstract
Nanomedicines (NMs) offer new solutions for cancer diagnosis and therapy. However, extension of progression-free interval and overall survival time achieved by Food and Drug Administration-approved NMs remain modest. To develop next generation NMs to achieve superior anticancer activities, it is crucial to investigate and understand the correlation between the physicochemical properties of NMs (particle size in particular) and their interactions with biological systems to establish criteria for NM optimization. Here, we systematically evaluated the size-dependent biological profiles of three monodisperse drug-silica nanoconjugates (NCs; 20, 50, and 200 nm) through both experiments and mathematical modeling and…
Citation impact
- FWCI
- 22.03
- Percentile
- 100%
- References
- 71
Authors
18Topics & keywords
- Nanomedicine
- Internalization
- Drug delivery
- In vivo
- Drug
- Food and drug administration
- Nanotechnology
- Dispersity
- Good health and well-being