Quantification of biological aging in young adults

Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. We developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. Our longitudinal measure allows…

• MR
  Medical Research Council

  Awards: MR/K00381X, MR/K00381X/1
• EA
  Economic and Social Research Council

  Award: ES/M010309/1
• NI
  National Institute on Aging

  Awards: AG048895, AG000029, AG028716, AG032282