Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Scott, Robert A.; Lagou, Vasiliki; Welch, Ryan; Wheeler, Eleanor; Montasser, May E.; Luan, Jian’an; Mägi, Reedik; Strawbridge, Rona J.; Rehnberg, Emil; Gustafsson, Stefan; Kanoni, Stavroula; Rasmussen‐Torvik, Laura J.; Yengo, Loïc; Lecœur, Cécile; Shungin, Dmitry; Sanna, Serena; Sidore, Carlo; Johnson, P.; Jukema, J. Wouter; Johnson, Toby; Mahajan, Anubha; Verweij, Niek; Þorleifsson, Guðmar; Hottenga, Jouke‐Jan; Shah, Sonia; Smith, Albert V.; Sennblad, Bengt; Gieger, Christian; Salo, Perttu; Perola, Markus; Timpson, Nicholas J.; Evans, David M.; Pourcain, Beaté St; Wu, Ying; Andrews, Jeanette S.; Hui, Jennie; Bielak, Lawrence F.; Zhao, Wei; Horikoshi, Momoko; Navarro, Pau; Isaacs, Aaron; O’Connell, Jeffrey R.; Stirrups, Kathleen; Vitart, Véronique; Hayward, Caroline; Esko, Tõnu; Mihailov, Evelin; Fraser, Ross M.; Fall, Tove; Voight, Benjamin F.; Raychaudhuri, Soumya; Chen, Han; Lindgren, Cecilia M.; Morris, Andrew P.; Rayner, Nigel W.; Robertson, Neil; Rybin, Denis; Liu, Ching‐Ti; Beckmann, J.; Willems, Sara M.; Chines, Peter S.; Jackson, Anne; Kang, Hyun Min; Stringham, Heather M.; Song, Kijoung; Tanaka, Toshiko; Peden, John F.; Goel, Anuj; Hicks, Andrew A.; An, Ping; Müller‐Nurasyid, Martina; Franco‐Cereceda, Anders; Folkersen, Lasse; Marullo, Letizia; Jansen, Hanneke; Oldehinkel, Albertine J.; Bruinenberg, Marcel; Pankow, James S.; North, Kari E.; Forouhi, Nita G.; Loos, Ruth J. F.; Edkins, Sarah; Varga, Tibor V.; Hallmans, Göran; Oksa, Heikki; Mulas, Antonella; Nagaraja, Ramaiah; Trompet, Stella; Ford, Ian; Bakker, Stephan J. L.; Kong, Augustine; Kumari, Meena; Gigante, Bruna; Herder, Christian; Munroe, Patricia B.; Caulfield, Mark J.; Antti, Jula; Mangino, Massimo; Small, Kerrin S.; Miljkovic, Iva; Liu, Ching‐Ti; Atalay, Mustafa; Kieß, Wieland; James, Alan L; Rivadeneira, Fernando; Uitterlinden, André G.; Palmer, Colin N A; Doney, Alex S. F.; Willemsen, Gonneke; Smit, Johannes H.; Campbell, Susan; Polašek, Ozren; Bonnycastle, Lori L.; Herçberg, Serge; Dimitriou, Maria; Bolton, Jennifer L.; Fowkes, Gerard R; Kovács, Péter; Lindström, Jaana; Zemunik, Tatijana; Bandinelli, Stefania; Wild, Sarah H.; Basart, Hanneke; Rathmann, Wolfgang; Grallert, Harald; Maerz, Winfried; Kleber, Marcus E.; Boehm, Bernhard O.; Peters, Annette; Pramstaller, Peter P.; Province, Michael A.; Borecki, Ingrid B.; Hastie, N D; Rudan, Igor; Campbell, Harry; Watkins, Hugh; Farrall, Martin; Stümvoll, Michael; Ferrucci, Luigi; Waterworth, Dawn; Bergman, Richard N.; Collins, Francis S.; Tuomilehto, Jaakko; Watanabe, Richard M.; Geus, Eco J. C. de; Penninx, Brenda W.J.H.; Hofman, Albert; Oostra, Ben A.; Psaty, Bruce M.; Vollenweider, Péter; Wilson, James F.; Wright, Alan F; Hovingh, G. Kees; Metspalu, Andres; Uusitupa, Matti; Magnusson, Patrik K. E.; Kyvik, Kirsten Ohm; Kaprio, Jaakko; Price, Jackie F.; Dedoussis, George; Deloukas, Panos; Meneton, Pierre; Lind, Lars; Boehnke, Michael; Shuldiner, Alan R.; Duijn, Cornelia M. van; Morris, Andrew D; Toenjes, Anke; Peyser, Patricia A.; Beilby, John; Körner, Antje; Kuusisto, Johanna; Laakso, Markku; Bornstein, Stefan R.; Schwarz, Peter E. H.; Lakka, Timo A.; Rauramaa, Rainer; Adair, Linda S.; Smith, George Davey; Spector, Tim D; Illig, Thomas; Fairé, Ulf dé; Hamsten, Anders; Guðnason, Vilmundur; Kivimäki, Mika; Hingorani, Aroon D.; Keinänen‐Kiukaanniemi, Sirkka; Saaristo, Timo; Boomsma, Dorret I.; Stefánsson, Kāri; Harst, Pim van der; Dupuis, Josée; Pedersen, Nancy L.; Sattar, Naveed; Harris, Tamara B.; Cucca, Francesco; Ripatti, Samuli; Salomaa, Veikko; Mohlke, Karen L; Balkau, Beverley; Froguel, Philippe; Pouta, Anneli; Järvelin, Marjo‐Riitta; Wareham, Nicholas J.; Bouatia‐Naji, Nabila; McCarthy, Mark I.; Franks, Paul W.; Meigs, James B.; Teslovich, Tanya M.; Florez, José C.; Langenberg, Claudia; Ingelsson, Erik; Prokopenko, Inga; Barroso, Inês

doi:10.1038/ng.2385

reviewNature GeneticsAug 12, 2012BRONZE OA

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

RARobert A. Scott VLVasiliki Lagou RWRyan Welch EWEleanor Wheeler MEMay E. Montasser

Addenbrooke's Hospital · MRC Epidemiology Unit · +91 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

857

total citations

FWCI: 42.51
Percentile: 100%
References: 103

Citations per year

Authors

214

RA
Robert A. Scott
Addenbrooke's Hospital, MRC Epidemiology Unit, Medical Research Council
VL
Vasiliki Lagou
Centre for Human Genetics, University of Oxford
RW
Ryan Welch
University of Michigan
EW
Eleanor Wheeler
Wellcome Sanger Institute
ME
May E. Montasser
University of Maryland, Baltimore

Topics & keywords

Topics

Genetic Associations and Epidemiology100%
Genetic Mapping and Diversity in Plants and Animals100%
Lipid metabolism and biosynthesis99%

Keywords

Biology
Genome-wide association study
Glycemic
Genetic association
Insulin resistance
Genetics
Type 2 diabetes
Quantitative trait locus

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

UD
U.S. Department of Agriculture
JD
John D. and Catherine T. MacArthur Foundation
Award: HS06516
G
GlaxoSmithKline
SO
School of Medicine, Boston University
JH
Johns Hopkins University
Award: N01-HG-65403
WT
Wellcome Trust
Awards: 076467, 092731, 74882
NI
National Institute for Health and Care Research
BH
British Heart Foundation
Awards: QLG2-CT-2002-01254, HS06516
T
Tenovus
EC
European Commission
Awards: QLG2-CT-2002-01254, 201413, 01254
HA
Health and Safety Executive
UO
University of Bristol
Awards: 74882, 076467, 092731
SF
Stiftelsen för Strategisk Forskning
H
Hjärt-Lungfonden
Award: HS06516
NN
Novo Nordisk
V
Vetenskapsrådet
Award: HS06516
AS
Akademiska Sjukhuset
UU
Uppsala Universitet
D
Diabetesliitto
PS
Pirkanmaan Sairaanhoitopiiri
TJ
Terveyden ja hyvinvoinnin laitos
NI
National Institutes of Health
Awards: DK080140, U01 HL84756, K24 DK080140, N01-HG-65403, R01 HL088119, M01 RR 16500, DK062370, R01-DK062370, R01 DK54261, R01 AG18728, 092731, P30 DK72488, R01 DK078616, U01 GM074518, DK078616, DK072193, HL087660
NI
National Institute of Food and Agriculture
MR
Medical Research Council
Awards: 74882, 076467, HS06516, 092731
EA
Economic and Social Research Council
NC
NIHR Cambridge Biomedical Research Centre
NI
National Institute on Aging
Awards: HS06516, AG13196
NI
National Institute of Diabetes and Digestive and Kidney Diseases
Awards: DK078616, K24 DK080140, DK072193, DK062370, R01 DK078616
MN
Mid-Atlantic Nutrition Obesity Research Center, School of Medicine, University of Maryland
FH
FP7 Health
Award: 201413