Population Genomics: Whole-Genome Analysis of Polymorphism and Divergence in Drosophila simulans

The population genetic perspective is that the processes shaping genomic variation can be revealed only through simultaneous investigation of sequence polymorphism and divergence within and between closely related species. Here we present a population genetic analysis of Drosophila simulans based on whole-genome shotgun sequencing of multiple inbred lines and comparison of the resulting data to genome assemblies of the closely related species, D. melanogaster and D. yakuba. We discovered previously unknown, large-scale fluctuations of polymorphism and divergence along chromosome arms, and significantly less polymorphism and faster divergence on the X chromosome. We generated a comprehensive list of functional…

• NS
  National Science Foundation

  Awards: CCF 03-47992, R01-HG02362, 0512106, 0434670
• PU
  Purdue University
• NS
  National Science Council
• NI
  National Institutes of Health

  Award: NIH R01
• NH
  National Human Genome Research Institute