Biphasic Dose Response in Low Level Light Therapy – an Update
Harvard University · Guangxi Medical University · +2 more institutions
Abstract
Low-level laser (light) therapy (LLLT) has been known since 1967 but still remains controversial due to incomplete understanding of the basic mechanisms and the selection of inappropriate dosimetric parameters that led to negative studies. The biphasic dose-response or Arndt-Schulz curve in LLLT has been shown both in vitro studies and in animal experiments. This review will provide an update to our previous (Huang et al. 2009) coverage of this topic. In vitro mediators of LLLT such as adenosine triphosphate (ATP) and mitochondrial membrane potential show biphasic patterns, while others such as mitochondrial reactive oxygen species show a triphasic dose-response with two distinct peaks. The Janus nature of…
Citation impact
- FWCI
- 12.88
- Percentile
- 100%
- References
- 53
Authors
4- YHYing‐Ying Huang
Harvard University, Guangxi Medical University, Massachusetts General Hospital
- SKSulbha K. Sharma
Massachusetts General Hospital
- JDJames D. Carroll
- MRMichael R. HamblinCorresponding
Harvard University, Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology
Topics & keywords
- In vivo
- Reactive oxygen species
- In vitro
- Pharmacology
- Mitochondrion
- Neuroscience
- Medicine
- Adenosine triphosphate
- Affordable and clean energy