Homologous recombination and its regulation

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on the control of Rad51 nucleofilaments that play a central role in HR. Some factors promote the formation of these structures while others lead to their disassembly or the use of alternative repair pathways. In this article, we review these mechanisms in both mitotic and meiotic environments and in different eukaryotic taxa, with an emphasis on yeast and mammal…

• GA
  Grantová Agentura České Republiky

  Awards: CZ.1.05/1.1.00/02.0123, 203/09/H046, GACR P207/12/2323, P207/12/2323, GACR 301/09/1917, GACR 203/09/H046
• ER
  European Regional Development Fund

  Award: CZ.1.05/1.1.00/02.0123
• NI
  National Institute of General Medical Sciences

  Award: GM080670