Evidence for Network Evolution in an Arabidopsis Interactome Map

Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a…

• NS
  National Science Foundation
• UD
  U.S. Department of Agriculture
• JS
  James S. McDonnell Foundation
• FD
  Fonds De La Recherche Scientifique - FNRS
• CE
  Canada Excellence Research Chairs, Government of Canada
• NI
  National Institutes of Health
• NH
  National Human Genome Research Institute
• NI
  National Institute of General Medical Sciences