Comprehensive molecular characterization of gastric adenocarcinoma

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding…

• NI
  National Institutes of Health

  Awards: U54HG003067, 5U24CA143883, 5U24CA144025, 5U24CA143799, P30CA16672, 5U24CA143867, U54HG003273, 5U24CA143866, U54HG003079, 5U24CA143835, 5U24CA143848, 5U24CA143858, 5U24CA143845, 5U24CA143840, 5U24CA143843, 5U24CA143882
• NH
  National Human Genome Research Institute

  Awards: U54HG003079, U54HG003273, U54HG003067
• NC
  National Cancer Institute

  Awards: 5U24CA143845, 5U24CA144025, U54HG003079