Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease
Harvard University · Athinoula A. Martinos Center for Biomedical Imaging · +3 more institutions
Abstract
Recent evidence suggests that some brain areas act as hubs interconnecting distinct, functionally specialized systems. These nexuses are intriguing because of their potential role in integration and also because they may augment metabolic cascades relevant to brain disease. To identify regions of high connectivity in the human cerebral cortex, we applied a computationally efficient approach to map the degree of intrinsic functional connectivity across the brain. Analysis of two separate functional magnetic resonance imaging datasets (each n = 24) demonstrated hubs throughout heteromodal areas of association cortex. Prominent hubs were located within posterior cingulate, lateral temporal, lateral parietal, and…
Citation impact
- FWCI
- 56.43
- Percentile
- 100%
- References
- 94
Authors
9- RLRandy L. BucknerCorresponding
Harvard University
- JSJorge Sepulcre
Harvard University, Athinoula A. Martinos Center for Biomedical Imaging, University Radiology
- TTTanveer Talukdar
Athinoula A. Martinos Center for Biomedical Imaging, University Radiology
- FMFenna M. Krienen
Harvard University, Athinoula A. Martinos Center for Biomedical Imaging
- HLHesheng Liu
Athinoula A. Martinos Center for Biomedical Imaging, University Radiology
Topics & keywords
- Neuroscience
- Default mode network
- Functional magnetic resonance imaging
- Posterior parietal cortex
- Posterior cingulate
- Neuroimaging
- Psychology
- Prefrontal cortex