The microbiota regulates type 2 immunity through RORγt + T cells

Changes to the symbiotic microbiota early in life, or the absence of it, can lead to exacerbated type 2 immunity and allergic inflammations. Although it is unclear how the microbiota regulates type 2 immunity, it is a strong inducer of proinflammatory T helper 17 (T(H)17) cells and regulatory T cells (T(regs)) in the intestine. Here, we report that microbiota-induced T(regs) express the nuclear hormone receptor RORγt and differentiate along a pathway that also leads to T(H)17 cells. In the absence of RORγt(+) T(regs), T(H)2-driven defense against helminths is more efficient, whereas T(H)2-associated pathology is exacerbated. Thus, the microbiota regulates type 2 responses through the induction of type 3…

• BI
  Boehringer Ingelheim
• EM
  European Molecular Biology Organization
• EC
  European Commission

  Award: MEXT-CT-2006-042374
• AN
  Agence Nationale de la Recherche

  Award: ANR 11 BSV3 020 01
• IP
  Institut Pasteur
• JS
  Japan Society for the Promotion of Science

  Award: 15K19129