An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
National Yang Ming Chiao Tung University · University of California System · +15 more institutions
Abstract
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospective cohort studies are needed to validate MN as a cancer risk biomarker. A total of 6718 subjects from of 10 countries, screened in 20 laboratories for MN frequency between 1980 and 2002 in ad hoc studies or routine cytogenetic surveillance, were selected from the database of the HUman MicroNucleus (HUMN) international collaborative project and followed up for cancer incidence or mortality. To standardize for the…
Citation impact
- FWCI
- 23.86
- Percentile
- 100%
- References
- 48
Authors
24Topics & keywords
- Micronucleus test
- Medicine
- Biomarker
- Cancer
- Population
- Micronucleus
- Internal medicine
- Incidence (geometry)
- Good health and well-being