Comparative Metagenomics of Microbial Communities
Lawrence Berkeley National Laboratory · Joint Genome Institute · +3 more institutions
Abstract
The species complexity of microbial communities and challenges in culturing representative isolates make it difficult to obtain assembled genomes. Here we characterize and compare the metabolic capabilities of terrestrial and marine microbial communities using largely unassembled sequence data obtained by shotgun sequencing DNA isolated from the various environments. Quantitative gene content analysis reveals habitat-specific fingerprints that reflect known characteristics of the sampled environments. The identification of environment-specific genes through a gene-centric comparative analysis presents new opportunities for interpreting and diagnosing environments.
Citation impact
- FWCI
- 41.31
- Percentile
- 100%
- References
- 21
Authors
13- SGSusannah G. TringeCorresponding
Lawrence Berkeley National Laboratory, Joint Genome Institute, Diversitech (United States), European Molecular Biology Laboratory, University of California, Berkeley
- CVChristian von MeringCorresponding
Lawrence Berkeley National Laboratory, Joint Genome Institute, Diversitech (United States), European Molecular Biology Laboratory, University of California, Berkeley
- AKArthur Kobayashi
Lawrence Berkeley National Laboratory, Joint Genome Institute, Diversitech (United States), European Molecular Biology Laboratory, University of California, Berkeley
- ASAsaf Salamov
Lawrence Berkeley National Laboratory, Joint Genome Institute, Diversitech (United States), European Molecular Biology Laboratory, University of California, Berkeley
- KCKevin Chen
Lawrence Berkeley National Laboratory, Joint Genome Institute, Diversitech (United States), European Molecular Biology Laboratory, University of California, Berkeley
Topics & keywords
- Metagenomics
- Biology
- Computational biology
- Identification (biology)
- Shotgun sequencing
- Genome
- Gene
- DNA sequencing
- Life below water
Funding
- UDU.S. Department of EnergyAwards: AC03-76SF00098, W-7405, 7405-Eng-48, DE-AC03, W-7405-Eng-48, W-7405-ENG-36
- NINational Institutes of HealthAward: DE-AC03-76SF00098
- BABiological and Environmental Research
- LLLawrence Livermore National LaboratoryAwards: -7405-Eng-48, DE-AC03-76SF00098, W-7405-ENG-36, W-7405-Eng-48
- LBLawrence Berkeley National LaboratoryAward: DE-AC03-76SF00098
- LALos Alamos National LaboratoryAward: W-7405-ENG-36