Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia
Université Claude Bernard Lyon 1 · Inserm · +5 more institutions
Abstract
The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model. Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal…
Citation impact
- FWCI
- 52.84
- Percentile
- 100%
- References
- 19
Authors
12- MLMaria Labandeira‐Rey
Université Claude Bernard Lyon 1, Inserm, Texas A&M University System, Université de Lyon, Hospices Civils de Lyon, Laboratoire National de Référence, Hôpital Edouard Herriot
- FCFlorence Couzon
Université Claude Bernard Lyon 1, Inserm, Texas A&M University System, Université de Lyon, Hospices Civils de Lyon, Laboratoire National de Référence, Hôpital Edouard Herriot
- SBSandrine Boisset
Université Claude Bernard Lyon 1, Inserm, Texas A&M University System, Université de Lyon, Hospices Civils de Lyon, Laboratoire National de Référence, Hôpital Edouard Herriot
- ELEric L. BrownCorresponding
Université Claude Bernard Lyon 1, Inserm, Texas A&M University System, Université de Lyon, Hospices Civils de Lyon, Laboratoire National de Référence, Hôpital Edouard Herriot
- MBMichèle Bes
Université Claude Bernard Lyon 1, Inserm, Texas A&M University System, Université de Lyon, Hospices Civils de Lyon, Laboratoire National de Référence, Hôpital Edouard Herriot
Topics & keywords
- Panton–Valentine leukocidin
- Leukocidin
- Staphylococcus aureus
- Microbiology
- Outbreak
- Pneumonia
- Toxin
- Biology
- Good health and well-being