IDH1 and IDH2 Mutations in Gliomas
Duke University · Pediatric Brain Tumor Foundation · +6 more institutions
Abstract
A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate dehydrogenase 1 gene (IDH1) in a fraction of such tumors, most frequently in tumors that were known to have evolved from lower-grade gliomas (secondary glioblastomas).
We determined the sequence of the IDH1 gene and the related IDH2 gene in 445 central nervous system (CNS) tumors and 494 non-CNS tumors. The enzymatic activity of the proteins that were produced from normal and mutant IDH1 and IDH2 genes was determined in cultured glioma cells that were transfected with these genes.
Citation impact
- FWCI
- 135.87
- Percentile
- 100%
- References
- 30
Authors
18- HYHai YanCorresponding
Duke University, Pediatric Brain Tumor Foundation
- DWD. Williams Parsons
Cancer Genetics (United States), Sidney Kimmel Cancer Center, Baylor College of Medicine, Howard Hughes Medical Institute
- GJGenglin Jin
Pediatric Brain Tumor Foundation
- RERoger E. McLendon
Pediatric Brain Tumor Foundation
- BAB. Ahmed Rasheed
Pediatric Brain Tumor Foundation
Topics & keywords
- IDH2
- IDH1
- Isocitrate dehydrogenase
- Glioma
- Gene
- Mutation
- Somatic cell
- Cancer research
- Good health and well-being