A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Ascertaining when and where genes are expressed is of crucial importance to understanding or predicting the physiological role of genes and proteins and how they interact to form the complex networks that underlie organ development and function. It is, therefore, crucial to determine on a genome-wide level, the spatio-temporal gene expression profiles at cellular resolution. This information is provided by colorimetric RNA in situ hybridization that can elucidate expression of genes in their native context and does so at cellular resolution. We generated what is to our knowledge the first genome-wide transcriptome atlas by RNA in situ hybridization of an entire mammalian organism, the developing mouse at…

• NS
  National Science Foundation
• AP
  Association pour la Recherche sur le Cancer
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
• MD
  Ministerio de Economía y Competitividad

  Award: CSD2007-00023
• M
  Max-Planck-Gesellschaft
• CD
  Centro de Investigación Biomédica en Red de Salud Mental
• MR
  Medical Research Council
• ID
  Instituto de Salud Carlos III

  Award: 00023