DNA–DNA hybridization values and their relationship to whole-genome sequence similarities
Michigan State University · Ghent University
Abstract
DNA-DNA hybridization (DDH) values have been used by bacterial taxonomists since the 1960s to determine relatedness between strains and are still the most important criterion in the delineation of bacterial species. Since the extent of hybridization between a pair of strains is ultimately governed by their respective genomic sequences, we examined the quantitative relationship between DDH values and genome sequence-derived parameters, such as the average nucleotide identity (ANI) of common genes and the percentage of conserved DNA. A total of 124 DDH values were determined for 28 strains for which genome sequences were available. The strains belong to six important and diverse groups of bacteria for which the…
Citation impact
- FWCI
- 10.09
- Percentile
- 100%
- References
- 44
Authors
6Topics & keywords
- Biology
- Genome
- Genetics
- Gene
- DNA
- DNA–DNA hybridization
- DNA sequencing
- genomic DNA
- Life in Land