An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging

In this paper we describe a method for retrospective estimation and correction of eddy current (EC)-induced distortions and subject movement in diffusion imaging. In addition a susceptibility-induced field can be supplied and will be incorporated into the calculations in a way that accurately reflects that the two fields (susceptibility- and EC-induced) behave differently in the presence of subject movement. The method is based on registering the individual volumes to a model free prediction of what each volume should look like, thereby enabling its use on high b-value data where the contrast is vastly different in different volumes. In addition we show that the linear EC-model commonly used is insufficient…

• NI
  National Institutes of Health

  Awards: EP/L023067/1, 1U54MH091657, 1U54MH091657-01
• EA
  Engineering and Physical Sciences Research Council

  Awards: L023067, EP/L023067, 1U54MH091657, EP/L023067/1, EP/L023067/1